Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases – 7,358,361

Abstract Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium… Read moreBiophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases – 7,358,361

Methods of preparing lymphocytes that express interleukin-2 and their use in the treatment of cancer – 7,381,405

Abstract The invention provides methods of preparing autologous T-lymphocytes for re-introduction into a patient having cancer, which method comprises obtaining peripheral blood mononuclear cells (PBMCs) from a patient immunized with an antigen of the cancer, stimulating the PBMCs with the… Read moreMethods of preparing lymphocytes that express interleukin-2 and their use in the treatment of cancer – 7,381,405

Methods of treating cancer using antibodies that immunospecifically bind to trail receptors – 7,361,341

Abstract The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules… Read moreMethods of treating cancer using antibodies that immunospecifically bind to trail receptors – 7,361,341

Method of treating cancer cells to create a modified cancer cell that provokes an immunogenic response – 7,361,360

Abstract The present invention relates to a delipidation method employing a solvent system useful for extracting lipids from cancer cells, thereby creating a modified cancer cell particle. Upon delipidation of the cancer cells, a portion of the cancer cell antigens… Read moreMethod of treating cancer cells to create a modified cancer cell that provokes an immunogenic response – 7,361,360

Serum macrophage migration inhibitory factor (MIF) as marker for prostate cancer – 7,361,474

Abstract The present invention provides methods for detecting, diagnosing or prognosticating prostate cancer by measuring the levels of macrophage migration inhibitory factor (MIF) in the serum of an individual. The assay for MIF can be an immunoassay, such as ELISA,… Read moreSerum macrophage migration inhibitory factor (MIF) as marker for prostate cancer – 7,361,474