Abstract
Bis-amido polybiguanides and their use as antimicrobial agents in pharmaceutical compositions are disclosed. A method of synthesis of bis-amido polybiguanides is also disclosed. The bis-amido polybiguanides are useful in the preservation of pharmaceutical compositions, particularly ophthalmic and otic pharmaceutical compositions and compositions for treating contact lenses. The compounds are especially useful for disinfecting/cleaning contact lenses.
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May 15, 2012
Bis-amido polybiguanides and the use thereof to disinfect contact lenses and preserve pharmaceutical compositions – 6,316,669
Device for packaging and treating bactericide for contact lenses – 6,318,549
Abstract
The invention relates to a packaging and bactericidal treatment device for contact lenses (L), said device being characterized in that it comprises: firstly a housing (1) provided with at least one cavity (10) receiving a support element (11) which has bactericidal action and whose outside face (11a) has curvature matching the curvature of the contact lenses (L); and secondly, at least one lid (2) designed to cover said cavity (10) and whose inside face is provided with at least one socket (20) which is suitable for being engaged in guided manner into said cavity (10), and which receives a wedge element (21) having bactericidal action and whose outside face (21a) has curvature complementary to the curvature of the support element (11) so that it protects and/or decontaminates a contact lens (L) by holding it stationary in said cavity (10) between said support element (11) and said wedge element (21)
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Compositions and methods to disinfect contact lenses – 6,338,847
Abstract
Compositions and methods to disinfect contact lenses are disclosed. In one embodiment, the present composition comprises a cellulose decomposing enzyme component, e.g., lysozyme, and a hydrogen peroxide destroying component. The composition is structured so that the cellulose decomposing enzyme component is released in a liquid medium containing hydrogen peroxide before the hydrogen peroxide destroying component is released in the liquid medium. Such cellulose decomposing enzyme component is preferably effective to render hydrogen peroxide-resistant microorganisms, e.g., acanthamoeba cysts, which may contaminate the lens more susceptible to being killed by hydrogen peroxide.
Packaging arrangement for contact lenses – RE37,558
Abstract
A packaging arrangement for the containment of at least one hydrophilic contact lens in a sterile aqueous solution. More specifically, pursuant to the packaging arrangement, a plurality of disposable hydrophilic contact lenses are contained in a specific number of individual packaging arrangements collectively housed in a box-like container or carton so as to provide a specified or essentially measured supply of contact lenses for use by a consumer over a predetermined period of time.
Ophthalmic anti-allergy compositions suitable for use with contact lenses – 6,375,973
Abstract
Topically administrable anti-allergy compositions comprising olopatadine and a polymeric quaternary ammonium preservative are suitable for use by patients wearing contact lenses.
Method for cast molding toric contact lenses – 6,383,419
Abstract
Methods of cast molding toric contact lenses are provided including the steps of providing a first contact lens mold section; providing a molding apparatus and an insert tool adapted to be fixed to the molding apparatus at a plurality of different rotational orientations relative to the molding apparatus; fixing, at one of a plurality of different rotational orientations relative to the molding apparatus, the insert tool in a molding apparatus and producing a second mold section in the molding apparatus with the insert tool fixed thereto, wherein the second mold section includes a contour which corresponds to a toric optical zone of a contact lens; assembling the first and second mold sections; and cast molding a toric contact lens product between the mold sections. Sets of mold sections useful for molding toric contact lenses as provided.
Process for preparing polyvinyl alcohol contact lenses – 6,402,995
Abstract
A process for preparing crosslinked polyvinyl alcohol contact lenses through hydrolysis of a copolymer of a vinyl ester with triallyl isocyanurate, which includes preparing a mixture of 100 parts by weight of the vinyl ester with 0.05 to 5 parts by weight of the triallyl isocyanurate, filling a mold composed of a male mold and a female mold with the mixture, applying ultraviolet ray to form a lens-shaped polymer, and hydrolyzing the resultant polymer. Since this process has a lens-shaped polymer formed without machinery processings, the lens surface is not roughened and the shape stability of the completed lens in a swollen state is so good that the handleability thereof is good and the lens can be mass-prepared with equalized quality.
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Method and apparatus for thermal bonding and packaging contact – 6,413,334
Abstract
In a method for the thermal bonding of a base part (3) of a packaging with a cover film (F), especially for the welding or sealing of a base part of a packaging for contact lenses with a cover film, the contact surface of the base part (3) facing the cover film (F) and the corresponding contact surface of the cover film (F) facing the base part are mechanically pressed against one another along a join. While the mechanical pressure is being generated along the join, heat is simultaneously caused to act on the join, so that the contact surfaces of base part (3) and cover film (F) are thermally bonded to one another along the join. For the purpose of generating the mechanical pressure and causing heat to act on the join there is used a contact plate (70) of low heat capacity which, during the thermal bonding, is pressed against the surface of the cover film (F) remote from the contact surface. The temperature of the contact plate is measured in the immediate vicinity of the cover film, and in the event of the measured temperature deviating from a predetermined tolerance range around a desired temperature, the temperature of the contact plate (70) is within a very short time adjusted so that is again lies within the predetermined tolerance range around the desired temperature.
Solution for contact lenses – 6,417,144
Abstract
A solution for contact lenses which comprises an amino acid type cationic surfactant and at least one nonionic surfactant.
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Method for cast molding contact lenses with a rounded edge form – 6,431,706
Abstract
Methods for producing contact lenses include providing a back surface tool having a surface generally corresponding to a desired contact lens surface and a convex curve along an outer radius thereof, positioning the tool in a molding apparatus, introducing a moldable material into the molding apparatus to form a first mold section having a negative impression of the surface of the tool, assembling the first mold section with a second mold section to form a lens shaped cavity therebetween and forming a contact lens member in the lens shaped cavity of the assembled mold sections. Molds useful in producing contact lenses, tools useful in making mold sections for molding contact lenses and contact lenses having rounded edge surfaces are also provided.